Drug interactions
Chlordiazepoxide-clidinium + Istradefylline
Severity: Minor
Chlordiazepoxide-clidinium and Istradefylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At higher doses istradefylline can raise exposure to CYP3A4 substrates such as chlordiazepoxide, increasing sedation and psychomotor impairment.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Istradefylline belongs to Central Nervous System.
Why it happens
Istradefylline weakly inhibits CYP3A4 at higher doses.
What to do
Monitor for increased sedation, especially with istradefylline 40 mg daily; reduce the chlordiazepoxide dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Istradefylline
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Istradefylline?
MediHelp rates the interaction as minor. Chlordiazepoxide-clidinium and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. At higher doses istradefylline can raise exposure to CYP3A4 substrates such as chlordiazepoxide, increasing sedation and psychomotor impairment.
How serious is the interaction between Chlordiazepoxide-clidinium and Istradefylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation, especially with istradefylline 40 mg daily; reduce the chlordiazepoxide dose if needed.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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