Drug interactions
Chlordiazepoxide-clidinium + Larotrectinib
Severity: Minor
Chlordiazepoxide-clidinium and Larotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate with weak inhibitory effect, and a meaningful rise in chlordiazepoxide exposure is unlikely. Any increase in sedation would be modest.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Larotrectinib belongs to Oncology.
Why it happens
Possible weak CYP3A4 inhibition by larotrectinib reducing chlordiazepoxide clearance.
What to do
Monitor for increased drowsiness when starting larotrectinib and lower the benzodiazepine dose if sedation develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Larotrectinib
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Larotrectinib?
MediHelp rates the interaction as minor. Chlordiazepoxide-clidinium and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate with weak inhibitory effect, and a meaningful rise in chlordiazepoxide exposure is unlikely. Any increase in sedation would be modest.
How serious is the interaction between Chlordiazepoxide-clidinium and Larotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased drowsiness when starting larotrectinib and lower the benzodiazepine dose if sedation develops.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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