Drug interactions
Chlordiazepoxide-clidinium + Lofexidine
Severity: Moderate
Chlordiazepoxide-clidinium and Lofexidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofexidine is a centrally acting alpha-2 agonist that causes sedation, hypotension and bradycardia, and it can add to benzodiazepine sedation. The combination increases the risk of oversedation and dizziness.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Lofexidine belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A potentiation and central alpha-2 agonism.
What to do
Monitor sedation, blood pressure and heart rate, and reduce doses if excessive drowsiness or hypotension develops. Counsel on driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Lofexidine?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofexidine is a centrally acting alpha-2 agonist that causes sedation, hypotension and bradycardia, and it can add to benzodiazepine sedation. The combination increases the risk of oversedation and dizziness.
How serious is the interaction between Chlordiazepoxide-clidinium and Lofexidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, blood pressure and heart rate, and reduce doses if excessive drowsiness or hypotension develops. Counsel on driving and alcohol.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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