Drug interactions
Chlordiazepoxide-clidinium + Lorazepam
Severity: Moderate
Chlordiazepoxide-clidinium and Lorazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Taking two benzodiazepines together produces additive central nervous system and respiratory depression. Excess sedation, impaired psychomotor performance, and falls can occur, especially in older adults.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Lorazepam belongs to Central Nervous System.
Why it happens
Both drugs enhance GABA-A receptor activity, giving additive CNS depression.
What to do
Avoid routine duplication of benzodiazepine therapy; if both are needed, use the lowest effective doses and monitor for sedation and respiratory depression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Lorazepam
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Lorazepam?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Taking two benzodiazepines together produces additive central nervous system and respiratory depression. Excess sedation, impaired psychomotor performance, and falls can occur, especially in older adults.
How serious is the interaction between Chlordiazepoxide-clidinium and Lorazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine duplication of benzodiazepine therapy; if both are needed, use the lowest effective doses and monitor for sedation and respiratory depression.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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