Drug interactions
Chlordiazepoxide-clidinium + Primidone
Severity: Moderate
Chlordiazepoxide-clidinium and Primidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone, partly metabolised to phenobarbital, adds sedation to chlordiazepoxide. Its enzyme-inducing effect may also reduce chlordiazepoxide concentrations.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Primidone belongs to Central Nervous System.
Why it happens
Additive CNS depression plus CYP3A4 induction by primidone and its phenobarbital metabolite.
What to do
Monitor sedation and therapeutic response, and adjust the benzodiazepine dose as needed. Avoid alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Primidone?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Primidone, partly metabolised to phenobarbital, adds sedation to chlordiazepoxide. Its enzyme-inducing effect may also reduce chlordiazepoxide concentrations.
How serious is the interaction between Chlordiazepoxide-clidinium and Primidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and therapeutic response, and adjust the benzodiazepine dose as needed. Avoid alcohol.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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