Drug interactions
Chlordiazepoxide-clidinium + Zuranolone
Severity: Major
Chlordiazepoxide-clidinium and Zuranolone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone causes CNS depression and driving impairment. Combined with chlordiazepoxide, sedation and psychomotor impairment may be increased.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Zuranolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Zuranolone belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A receptor modulation by both drugs.
What to do
Avoid the combination if possible; if necessary, reduce the dose of one or both drugs and counsel the patient about impairment of driving and alertness.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Zuranolone?
MediHelp rates the interaction as major. Chlordiazepoxide-clidinium and Zuranolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Zuranolone causes CNS depression and driving impairment. Combined with chlordiazepoxide, sedation and psychomotor impairment may be increased.
How serious is the interaction between Chlordiazepoxide-clidinium and Zuranolone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; if necessary, reduce the dose of one or both drugs and counsel the patient about impairment of driving and alertness.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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