Drug interactions
Chloroquine + Droperidol
Severity: Contraindicated
Chloroquine and Droperidol: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval, and droperidol carries a boxed warning for torsades de pointes. Combined use markedly raises the risk of life-threatening ventricular arrhythmia.
What this interaction means in plain words
Chloroquine and Droperidol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive blockade of cardiac repolarising potassium currents causing QT prolongation.
What to do
Avoid the combination; choose a non-QT-prolonging antiemetic or sedative.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
- Chloroquine + Quinidine Contraindicated
Frequently asked questions
Can I take Chloroquine with Droperidol?
MediHelp rates the interaction as contraindicated. Chloroquine and Droperidol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval, and droperidol carries a boxed warning for torsades de pointes. Combined use markedly raises the risk of life-threatening ventricular arrhythmia.
How serious is the interaction between Chloroquine and Droperidol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; choose a non-QT-prolonging antiemetic or sedative.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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