Drug interactions
Chloroquine + Panobinostat
Severity: Contraindicated
Chloroquine and Panobinostat: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Panobinostat significantly prolongs the QT interval and its labeling advises against use with other QT-prolonging drugs such as chloroquine. Combined use increases the risk of torsades de pointes and sudden cardiac death.
What this interaction means in plain words
Chloroquine and Panobinostat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Chloroquine belongs to Anti Parasitic; Panobinostat belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarization (QTc).
What to do
Do not combine; use a non-QT-prolonging alternative to chloroquine during panobinostat therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Pimozide Contraindicated
- Chloroquine + Quinidine Contraindicated
Other interactions of Panobinostat
- Amiodarone + Panobinostat Contraindicated
- Anagrelide + Panobinostat Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
- Dronedarone + Panobinostat Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Moxifloxacin + Panobinostat Contraindicated
Frequently asked questions
Can I take Chloroquine with Panobinostat?
MediHelp rates the interaction as contraindicated. Chloroquine and Panobinostat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Panobinostat significantly prolongs the QT interval and its labeling advises against use with other QT-prolonging drugs such as chloroquine. Combined use increases the risk of torsades de pointes and sudden cardiac death.
How serious is the interaction between Chloroquine and Panobinostat?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use a non-QT-prolonging alternative to chloroquine during panobinostat therapy.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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