Drug interactions
Chlorothiazide + Chlorpropamide
Severity: Moderate
Chlorothiazide and Chlorpropamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose and reduce the effect of chlorpropamide. Both drugs can also lower sodium, so hyponatremia may be more likely.
What this interaction means in plain words
Chlorothiazide and Chlorpropamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorothiazide belongs to Cardiovascular; Chlorpropamide belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism via thiazide-induced hypokalemia and reduced insulin secretion and sensitivity.
What to do
Monitor blood glucose and serum sodium and potassium. Adjust the antidiabetic dose as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpropamide
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Chlorpropamide?
MediHelp rates the interaction as moderate. Chlorothiazide and Chlorpropamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics can raise blood glucose and reduce the effect of chlorpropamide. Both drugs can also lower sodium, so hyponatremia may be more likely.
How serious is the interaction between Chlorothiazide and Chlorpropamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and serum sodium and potassium. Adjust the antidiabetic dose as required.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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