Drug interactions
Chlorothiazide + Deflazacort
Severity: Moderate
Chlorothiazide and Deflazacort: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics and corticosteroids both promote potassium loss. Together they can cause hypokalemia, with a risk of arrhythmias and muscle weakness, especially in patients on digoxin or with heart disease.
What this interaction means in plain words
Chlorothiazide and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorothiazide belongs to Cardiovascular; Deflazacort belongs to Miscellaneous.
Why it happens
Additive renal potassium wasting from thiazide distal tubular effects and corticosteroid mineralocorticoid activity.
What to do
Monitor serum potassium and magnesium periodically and supplement or add a potassium-sparing agent if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Deflazacort?
MediHelp rates the interaction as moderate. Chlorothiazide and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics and corticosteroids both promote potassium loss. Together they can cause hypokalemia, with a risk of arrhythmias and muscle weakness, especially in patients on digoxin or with heart disease.
How serious is the interaction between Chlorothiazide and Deflazacort?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium periodically and supplement or add a potassium-sparing agent if needed.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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