Drug interactions
Chlorothiazide + Dexamethasone
Severity: Moderate
Chlorothiazide and Dexamethasone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs promote potassium loss, so together they raise the risk of hypokalemia. This may be relevant in patients with heart disease or on digoxin.
What this interaction means in plain words
Chlorothiazide and Dexamethasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorothiazide belongs to Cardiovascular; Dexamethasone belongs to Endocrine.
Why it happens
Additive renal potassium excretion.
What to do
Monitor serum potassium and magnesium and replace as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Dexamethasone?
MediHelp rates the interaction as moderate. Chlorothiazide and Dexamethasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs promote potassium loss, so together they raise the risk of hypokalemia. This may be relevant in patients with heart disease or on digoxin.
How serious is the interaction between Chlorothiazide and Dexamethasone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium and replace as needed.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Mifepristone, Rilpivirine. The full list is on the Dexamethasone page.
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