Drug interactions
Chlorothiazide + Dobutamine
Severity: Moderate
Chlorothiazide and Dobutamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorothiazide causes renal potassium loss, and dobutamine can further lower serum potassium through beta-2 mediated cellular uptake. The combination may cause hypokalemia, raising the risk of arrhythmias.
What this interaction means in plain words
Chlorothiazide and Dobutamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorothiazide belongs to Cardiovascular; Dobutamine belongs to Cardiovascular.
Why it happens
Additive potassium lowering via renal excretion (thiazide) and intracellular shift (dobutamine).
What to do
Monitor serum potassium and magnesium during dobutamine infusion and replace as needed. Monitor the ECG for arrhythmias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dobutamine
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Dobutamine?
MediHelp rates the interaction as moderate. Chlorothiazide and Dobutamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorothiazide causes renal potassium loss, and dobutamine can further lower serum potassium through beta-2 mediated cellular uptake. The combination may cause hypokalemia, raising the risk of arrhythmias.
How serious is the interaction between Chlorothiazide and Dobutamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium during dobutamine infusion and replace as needed. Monitor the ECG for arrhythmias.
What other medicines interact with Dobutamine?
MediHelp also lists interactions of Dobutamine with, for example, Budesonide-formoterol, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Dobutamine page.
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