Drug interactions
Chlorothiazide + Drospirenone
Severity: Minor
Chlorothiazide and Drospirenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorothiazide promotes potassium loss while drospirenone promotes retention, so the net effect on potassium is unpredictable but usually small.
What this interaction means in plain words
Chlorothiazide and Drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorothiazide belongs to Cardiovascular; Drospirenone belongs to Endocrine.
Why it happens
Opposing effects on potassium: thiazide kaliuresis versus antimineralocorticoid retention.
What to do
Check serum potassium after starting the combination and adjust per results.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Drospirenone
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Drospirenone?
MediHelp rates the interaction as minor. Chlorothiazide and Drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chlorothiazide promotes potassium loss while drospirenone promotes retention, so the net effect on potassium is unpredictable but usually small.
How serious is the interaction between Chlorothiazide and Drospirenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium after starting the combination and adjust per results.
What other medicines interact with Drospirenone?
MediHelp also lists interactions of Drospirenone with, for example, Belzutifan, Bosentan, Carbamazepine. The full list is on the Drospirenone page.
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