Drug interactions
Chlorothiazide + Empagliflozin-metformin
Severity: Moderate
Chlorothiazide and Empagliflozin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Empagliflozin with a thiazide diuretic increases urine output and can lead to volume depletion, hypotension and electrolyte disturbance. Thiazides can also modestly worsen glycemic control.
What this interaction means in plain words
Chlorothiazide and Empagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorothiazide belongs to Cardiovascular; Empagliflozin-metformin belongs to Endocrine.
Why it happens
Additive diuretic and natriuretic effects.
What to do
Monitor hydration, blood pressure, electrolytes and renal function, and lower the diuretic dose if volume depletion occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Empagliflozin-metformin?
MediHelp rates the interaction as moderate. Chlorothiazide and Empagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Empagliflozin with a thiazide diuretic increases urine output and can lead to volume depletion, hypotension and electrolyte disturbance. Thiazides can also modestly worsen glycemic control.
How serious is the interaction between Chlorothiazide and Empagliflozin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hydration, blood pressure, electrolytes and renal function, and lower the diuretic dose if volume depletion occurs.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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