Drug interactions
Chlorothiazide + Eprosartan-hydrochlorothiazide
Severity: Moderate
Chlorothiazide and Eprosartan-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorothiazide duplicates the thiazide component already present, increasing the risk of hypokalemia, hyponatremia, hypotension and renal impairment without meaningful added benefit.
What this interaction means in plain words
Chlorothiazide and Eprosartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorothiazide belongs to Cardiovascular; Eprosartan-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive inhibition of the distal tubule sodium-chloride cotransporter, producing greater electrolyte and volume loss.
What to do
Avoid combining two thiazide diuretics and discontinue the duplicate. Check electrolytes and renal function if both were used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Eprosartan-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Chlorothiazide and Eprosartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorothiazide duplicates the thiazide component already present, increasing the risk of hypokalemia, hyponatremia, hypotension and renal impairment without meaningful added benefit.
How serious is the interaction between Chlorothiazide and Eprosartan-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two thiazide diuretics and discontinue the duplicate. Check electrolytes and renal function if both were used.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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