Drug interactions
Chlorothiazide + Flurbiprofen
Severity: Moderate
Chlorothiazide and Flurbiprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the diuretic and antihypertensive effect of thiazides and raise the risk of renal impairment, especially in volume-depleted patients.
What this interaction means in plain words
Chlorothiazide and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorothiazide belongs to Cardiovascular; Flurbiprofen belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins causes sodium and water retention and reduced renal perfusion, opposing thiazide action.
What to do
Monitor blood pressure, fluid status, renal function and electrolytes. Use the lowest effective NSAID dose and ensure adequate hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Flurbiprofen?
MediHelp rates the interaction as moderate. Chlorothiazide and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce the diuretic and antihypertensive effect of thiazides and raise the risk of renal impairment, especially in volume-depleted patients.
How serious is the interaction between Chlorothiazide and Flurbiprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status, renal function and electrolytes. Use the lowest effective NSAID dose and ensure adequate hydration.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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