Drug interactions
Chlorothiazide + Glipizide-metformin
Severity: Moderate
Chlorothiazide and Glipizide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose and reduce the effectiveness of antidiabetic drugs, particularly at higher doses. Patients taking glipizide-metformin may lose glycemic control when chlorothiazide is started or its dose is increased.
What this interaction means in plain words
Chlorothiazide and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorothiazide belongs to Cardiovascular; Glipizide-metformin belongs to Endocrine.
Why it happens
Thiazides cause hypokalemia and reduced insulin secretion and peripheral insulin sensitivity, which opposes the glucose-lowering action of sulfonylureas and metformin.
What to do
Monitor blood glucose and HbA1c after starting or changing the thiazide dose, and adjust the antidiabetic regimen if needed. Check serum potassium and renal function periodically.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Glipizide-metformin?
MediHelp rates the interaction as moderate. Chlorothiazide and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics can raise blood glucose and reduce the effectiveness of antidiabetic drugs, particularly at higher doses. Patients taking glipizide-metformin may lose glycemic control when chlorothiazide is started or its dose is increased.
How serious is the interaction between Chlorothiazide and Glipizide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or changing the thiazide dose, and adjust the antidiabetic regimen if needed. Check serum potassium and renal function periodically.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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