Drug interactions
Chlorothiazide + Glyburide-metformin
Severity: Moderate
Chlorothiazide and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorothiazide can raise blood glucose and may weaken the effect of glyburide and metformin. The effect is usually modest but can matter in patients with marginal control.
What this interaction means in plain words
Chlorothiazide and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorothiazide belongs to Cardiovascular; Glyburide-metformin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through thiazide-induced hypokalemia, impaired insulin secretion and increased insulin resistance.
What to do
Monitor blood glucose and HbA1c after starting or adjusting the diuretic and correct hypokalemia. Increase the antidiabetic therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Glyburide-metformin?
MediHelp rates the interaction as moderate. Chlorothiazide and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorothiazide can raise blood glucose and may weaken the effect of glyburide and metformin. The effect is usually modest but can matter in patients with marginal control.
How serious is the interaction between Chlorothiazide and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or adjusting the diuretic and correct hypokalemia. Increase the antidiabetic therapy if control worsens.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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