Drug interactions
Chlorothiazide + Hydrochlorothiazide-valsartan
Severity: Moderate
Chlorothiazide and Hydrochlorothiazide-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This is a duplication of thiazide diuretic therapy. The combination increases the risk of hypokalemia, hyponatremia, hypotension, volume depletion and metabolic disturbances without meaningful added benefit.
What this interaction means in plain words
Chlorothiazide and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorothiazide belongs to Cardiovascular; Hydrochlorothiazide-valsartan belongs to Cardiovascular.
Why it happens
Additive inhibition of the distal tubule sodium-chloride cotransporter with increased urinary electrolyte loss.
What to do
Avoid concurrent use of two thiazides; use one agent. If unavoidable, monitor electrolytes, renal function and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Hydrochlorothiazide-valsartan?
MediHelp rates the interaction as moderate. Chlorothiazide and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. This is a duplication of thiazide diuretic therapy. The combination increases the risk of hypokalemia, hyponatremia, hypotension, volume depletion and metabolic disturbances without meaningful added benefit.
How serious is the interaction between Chlorothiazide and Hydrochlorothiazide-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two thiazides; use one agent. If unavoidable, monitor electrolytes, renal function and blood pressure.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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