Drug interactions
Chlorothiazide + Ibuprofen
Severity: Moderate
Chlorothiazide and Ibuprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibuprofen can diminish the diuretic and blood pressure lowering effects of chlorothiazide. The combination may also raise the risk of acute kidney injury, especially with dehydration or in older patients.
What this interaction means in plain words
Chlorothiazide and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorothiazide belongs to Cardiovascular; Ibuprofen belongs to Musculoskeletal.
Why it happens
Ibuprofen inhibits renal prostaglandin synthesis, causing sodium and water retention and reduced renal blood flow, antagonizing thiazide effects.
What to do
Monitor blood pressure, edema, and renal function and electrolytes during combined use. Use the lowest effective NSAID dose for the shortest time or substitute paracetamol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chlorothiazide and Ibuprofen, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Ibuprofen?
MediHelp rates the interaction as moderate. Chlorothiazide and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ibuprofen can diminish the diuretic and blood pressure lowering effects of chlorothiazide. The combination may also raise the risk of acute kidney injury, especially with dehydration or in older patients.
How serious is the interaction between Chlorothiazide and Ibuprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, edema, and renal function and electrolytes during combined use. Use the lowest effective NSAID dose for the shortest time or substitute paracetamol.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
