Drug interactions
Chlorothiazide + Insulin degludec-liraglutide
Severity: Moderate
Chlorothiazide and Insulin degludec-liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorothiazide can raise blood glucose and reduce the effectiveness of insulin and liraglutide. Glycemic control may worsen, particularly when the diuretic is started or the dose is increased.
What this interaction means in plain words
Chlorothiazide and Insulin degludec-liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorothiazide belongs to Cardiovascular; Insulin degludec-liraglutide belongs to Endocrine.
Why it happens
Thiazides reduce insulin sensitivity and secretion, partly through hypokalemia, opposing the glucose-lowering effect.
What to do
Monitor blood glucose and potassium when starting or changing the thiazide dose. Correct hypokalemia and adjust the insulin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Insulin degludec-liraglutide?
MediHelp rates the interaction as moderate. Chlorothiazide and Insulin degludec-liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorothiazide can raise blood glucose and reduce the effectiveness of insulin and liraglutide. Glycemic control may worsen, particularly when the diuretic is started or the dose is increased.
How serious is the interaction between Chlorothiazide and Insulin degludec-liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and potassium when starting or changing the thiazide dose. Correct hypokalemia and adjust the insulin dose as needed.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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