Drug interactions
Chlorothiazide + Naproxen
Severity: Moderate
Chlorothiazide and Naproxen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naproxen can reduce the diuretic and antihypertensive effect of chlorothiazide. In patients who are volume depleted or have reduced renal function, the combination also raises the risk of acute kidney injury.
What this interaction means in plain words
Chlorothiazide and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorothiazide belongs to Cardiovascular; Naproxen belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal blood flow and sodium excretion, opposing thiazide natriuresis.
What to do
Monitor blood pressure, fluid status, serum creatinine and electrolytes when starting or continuing the combination. Ensure adequate hydration and avoid prolonged NSAID use where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Naproxen?
MediHelp rates the interaction as moderate. Chlorothiazide and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Naproxen can reduce the diuretic and antihypertensive effect of chlorothiazide. In patients who are volume depleted or have reduced renal function, the combination also raises the risk of acute kidney injury.
How serious is the interaction between Chlorothiazide and Naproxen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status, serum creatinine and electrolytes when starting or continuing the combination. Ensure adequate hydration and avoid prolonged NSAID use where possible.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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