Drug interactions
Chlorothiazide + Propranolol
Severity: Minor
Chlorothiazide and Propranolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination is commonly used for hypertension and is generally effective. Thiazide-induced hypokalemia and hyperglycemia are the main concerns, and propranolol may mask hypoglycemia.
What this interaction means in plain words
Chlorothiazide and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorothiazide belongs to Cardiovascular; Propranolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects; thiazide potassium loss and glucose intolerance combine with beta-blocker metabolic effects.
What to do
Monitor blood pressure, serum potassium and glucose periodically.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Propranolol?
MediHelp rates the interaction as minor. Chlorothiazide and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The combination is commonly used for hypertension and is generally effective. Thiazide-induced hypokalemia and hyperglycemia are the main concerns, and propranolol may mask hypoglycemia.
How serious is the interaction between Chlorothiazide and Propranolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum potassium and glucose periodically.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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