Drug interactions
Chlorothiazide + Sacubitril-valsartan
Severity: Moderate
Chlorothiazide and Sacubitril-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorothiazide lowers potassium while valsartan raises it, so the net effect varies. The combination adds to blood pressure lowering and may cause volume depletion or renal changes.
What this interaction means in plain words
Chlorothiazide and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorothiazide belongs to Cardiovascular; Sacubitril-valsartan belongs to Cardiovascular.
Why it happens
Additive hypotensive and volume-depleting effects with opposing effects on potassium excretion.
What to do
Monitor blood pressure, renal function and electrolytes after starting or adjusting either drug. Reduce the diuretic dose if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Sacubitril-valsartan?
MediHelp rates the interaction as moderate. Chlorothiazide and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorothiazide lowers potassium while valsartan raises it, so the net effect varies. The combination adds to blood pressure lowering and may cause volume depletion or renal changes.
How serious is the interaction between Chlorothiazide and Sacubitril-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and electrolytes after starting or adjusting either drug. Reduce the diuretic dose if hypotension develops.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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