Drug interactions
Chlorothiazide + Safinamide
Severity: Minor
Chlorothiazide and Safinamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Safinamide may inhibit intestinal BCRP, which could increase absorption of BCRP substrates. A modest rise in chlorothiazide exposure is possible.
What this interaction means in plain words
Chlorothiazide and Safinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorothiazide belongs to Cardiovascular; Safinamide belongs to Central Nervous System.
Why it happens
Inhibition of intestinal BCRP efflux increases chlorothiazide absorption.
What to do
Monitor blood pressure, fluid status and electrolytes when safinamide is started. No dose change is usually required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Safinamide?
MediHelp rates the interaction as minor. Chlorothiazide and Safinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Safinamide may inhibit intestinal BCRP, which could increase absorption of BCRP substrates. A modest rise in chlorothiazide exposure is possible.
How serious is the interaction between Chlorothiazide and Safinamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status and electrolytes when safinamide is started. No dose change is usually required.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Amphetamine polistirex. The full list is on the Safinamide page.
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