Drug interactions
Chlorothiazide + Spironolactone
Severity: Minor
Chlorothiazide and Spironolactone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Spironolactone is potassium-sparing while chlorothiazide promotes potassium loss, so the combination often balances potassium and is used deliberately. Additive diuresis can still cause volume depletion, hyponatremia or electrolyte shifts.
What this interaction means in plain words
Chlorothiazide and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorothiazide belongs to Cardiovascular; Spironolactone belongs to Cardiovascular.
Why it happens
Opposing renal potassium handling plus additive sodium and water excretion at different nephron sites.
What to do
Monitor serum potassium, sodium, renal function and volume status periodically.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chlorothiazide and Spironolactone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Spironolactone?
MediHelp rates the interaction as minor. Chlorothiazide and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Spironolactone is potassium-sparing while chlorothiazide promotes potassium loss, so the combination often balances potassium and is used deliberately. Additive diuresis can still cause volume depletion, hyponatremia or electrolyte shifts.
How serious is the interaction between Chlorothiazide and Spironolactone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, sodium, renal function and volume status periodically.
What other medicines interact with Spironolactone?
MediHelp also lists interactions of Spironolactone with, for example, Amiloride, Eplerenone, Triamterene. The full list is on the Spironolactone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
