Drug interactions
Chlorothiazide + Timolol
Severity: Minor
Chlorothiazide and Timolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The two are often combined for hypertension with additive blood pressure lowering. Thiazides may cause hypokalemia and impair glucose tolerance, which may be relevant with beta-blockers.
What this interaction means in plain words
Chlorothiazide and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorothiazide belongs to Cardiovascular; Timolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects, with thiazide-induced potassium loss and metabolic effects.
What to do
Monitor blood pressure, serum potassium and glucose periodically.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chlorothiazide and Timolol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Timolol?
MediHelp rates the interaction as minor. Chlorothiazide and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The two are often combined for hypertension with additive blood pressure lowering. Thiazides may cause hypokalemia and impair glucose tolerance, which may be relevant with beta-blockers.
How serious is the interaction between Chlorothiazide and Timolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum potassium and glucose periodically.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Timolol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
