Drug interactions
Chlorothiazide + Tretinoin
Severity: Minor
Chlorothiazide and Tretinoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause photosensitivity, so combined use may increase the risk of sunburn-like skin reactions. The effect is mainly relevant with oral tretinoin and sun exposure.
What this interaction means in plain words
Chlorothiazide and Tretinoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorothiazide belongs to Cardiovascular; Tretinoin belongs to Dermatology.
Why it happens
Additive photosensitizing effects of the two drugs.
What to do
Advise sun avoidance, protective clothing and broad-spectrum sunscreen. Review skin reactions at follow-up.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tretinoin
- Doxycycline + Tretinoin Major
- Minocycline + Tretinoin Major
- Omadacycline + Tretinoin Major
- Palovarotene + Tretinoin Major
- Sarecycline + Tretinoin Major
- Tetracycline + Tretinoin Major
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Tretinoin?
MediHelp rates the interaction as minor. Chlorothiazide and Tretinoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs can cause photosensitivity, so combined use may increase the risk of sunburn-like skin reactions. The effect is mainly relevant with oral tretinoin and sun exposure.
How serious is the interaction between Chlorothiazide and Tretinoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise sun avoidance, protective clothing and broad-spectrum sunscreen. Review skin reactions at follow-up.
What other medicines interact with Tretinoin?
MediHelp also lists interactions of Tretinoin with, for example, Doxycycline, Minocycline, Omadacycline. The full list is on the Tretinoin page.
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