Drug interactions
Chlorothiazide + Valganciclovir
Severity: Minor
Chlorothiazide and Valganciclovir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorothiazide is a renally secreted organic acid that could compete with ganciclovir for tubular elimination. Diuretic-induced volume depletion may also reduce renal clearance. The overall effect is expected to be small.
What this interaction means in plain words
Chlorothiazide and Valganciclovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorothiazide belongs to Cardiovascular; Valganciclovir belongs to Anti Virals.
Why it happens
Possible competition for renal tubular anion secretion; volume depletion may reduce clearance.
What to do
No routine change is needed. Monitor renal function and blood counts, and adjust valganciclovir to renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chlorothiazide and Valganciclovir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Valganciclovir
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Valganciclovir?
MediHelp rates the interaction as minor. Chlorothiazide and Valganciclovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chlorothiazide is a renally secreted organic acid that could compete with ganciclovir for tubular elimination. Diuretic-induced volume depletion may also reduce renal clearance. The overall effect is expected to be small.
How serious is the interaction between Chlorothiazide and Valganciclovir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Monitor renal function and blood counts, and adjust valganciclovir to renal function.
What other medicines interact with Valganciclovir?
MediHelp also lists interactions of Valganciclovir with, for example, Didanosine, Ganciclovir, Liposomal doxorubicin. The full list is on the Valganciclovir page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
