Drug interactions
Chlorothiazide + Valsartan
Severity: Minor
Chlorothiazide and Valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan with a thiazide diuretic gives additive blood pressure lowering and is a standard combination. Valsartan partly offsets thiazide-induced hypokalemia. Volume depletion may cause hypotension or renal function changes.
What this interaction means in plain words
Chlorothiazide and Valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorothiazide belongs to Cardiovascular; Valsartan belongs to Cardiovascular.
Why it happens
Complementary antihypertensive mechanisms, with ARB potassium retention offsetting thiazide kaliuresis.
What to do
Monitor blood pressure, electrolytes and creatinine after starting or changing doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Valsartan?
MediHelp rates the interaction as minor. Chlorothiazide and Valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valsartan with a thiazide diuretic gives additive blood pressure lowering and is a standard combination. Valsartan partly offsets thiazide-induced hypokalemia. Volume depletion may cause hypotension or renal function changes.
How serious is the interaction between Chlorothiazide and Valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, electrolytes and creatinine after starting or changing doses.
What other medicines interact with Valsartan?
MediHelp also lists interactions of Valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Valsartan page.
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