Drug interactions
Chlorpheniramine + Dosulepin
Severity: Moderate
Chlorpheniramine and Dosulepin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation and have anticholinergic activity, so using them together increases drowsiness, impaired psychomotor performance and anticholinergic effects such as dry mouth, constipation and urinary retention. Older adults are particularly vulnerable to confusion and falls.
What this interaction means in plain words
Chlorpheniramine and Dosulepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpheniramine belongs to Respiratory; Dosulepin belongs to Central Nervous System.
Why it happens
Additive central H1-receptor antagonism and muscarinic blockade.
What to do
Warn the patient about drowsiness and avoid driving or operating machinery until the response is known. Prefer a non-sedating antihistamine, particularly in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpheniramine
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Chlorpheniramine with Dosulepin?
MediHelp rates the interaction as moderate. Chlorpheniramine and Dosulepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation and have anticholinergic activity, so using them together increases drowsiness, impaired psychomotor performance and anticholinergic effects such as dry mouth, constipation and urinary retention. Older adults are particularly vulnerable to confusion and falls.
How serious is the interaction between Chlorpheniramine and Dosulepin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn the patient about drowsiness and avoid driving or operating machinery until the response is known. Prefer a non-sedating antihistamine, particularly in older patients.
What other medicines interact with Chlorpheniramine?
MediHelp also lists interactions of Chlorpheniramine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Chlorpheniramine page.
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