Drug interactions
Chlorpheniramine + Hyaluronidase
Severity: Minor
Chlorpheniramine and Hyaluronidase: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antihistamines in large systemic doses have been reported to make tissues partly resistant to hyaluronidase. A larger amount of hyaluronidase might be needed to achieve the same spreading effect.
What this interaction means in plain words
Chlorpheniramine and Hyaluronidase have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorpheniramine belongs to Respiratory; Hyaluronidase belongs to Miscellaneous.
Why it happens
Antihistamines may reduce tissue responsiveness to hyaluronidase; the mechanism is not clearly established.
What to do
If dispersion is inadequate in a patient taking high-dose antihistamines, a higher hyaluronidase dose may be required. No routine adjustment is needed at usual antihistamine doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlorpheniramine
Other interactions of Hyaluronidase
Frequently asked questions
Can I take Chlorpheniramine with Hyaluronidase?
MediHelp rates the interaction as minor. Chlorpheniramine and Hyaluronidase have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antihistamines in large systemic doses have been reported to make tissues partly resistant to hyaluronidase. A larger amount of hyaluronidase might be needed to achieve the same spreading effect.
How serious is the interaction between Chlorpheniramine and Hyaluronidase?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If dispersion is inadequate in a patient taking high-dose antihistamines, a higher hyaluronidase dose may be required. No routine adjustment is needed at usual antihistamine doses.
What other medicines interact with Chlorpheniramine?
MediHelp also lists interactions of Chlorpheniramine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Chlorpheniramine page.
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