Drug interactions
Chlorpheniramine + Oxazepam
Severity: Moderate
Chlorpheniramine and Oxazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpheniramine is a sedating antihistamine that can add to the drowsiness caused by oxazepam. Impaired alertness and slowed reaction times are likely, especially in older adults.
What this interaction means in plain words
Chlorpheniramine and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpheniramine belongs to Respiratory; Oxazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression via H1-receptor antagonism and GABA-A potentiation.
What to do
Counsel patients to avoid driving and alcohol, or switch to a non-sedating antihistamine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Other interactions of Chlorpheniramine
Frequently asked questions
Can I take Chlorpheniramine with Oxazepam?
MediHelp rates the interaction as moderate. Chlorpheniramine and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpheniramine is a sedating antihistamine that can add to the drowsiness caused by oxazepam. Impaired alertness and slowed reaction times are likely, especially in older adults.
How serious is the interaction between Chlorpheniramine and Oxazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to avoid driving and alcohol, or switch to a non-sedating antihistamine.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
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