Drug interactions
Chlorpheniramine + Zuranolone
Severity: Moderate
Chlorpheniramine and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone causes somnolence and driving impairment, and sedating antihistamines add to these effects. The combination may increase CNS depression and psychomotor impairment.
What this interaction means in plain words
Chlorpheniramine and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpheniramine belongs to Respiratory; Zuranolone belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A modulation plus H1 antagonism.
What to do
Prefer a non-sedating antihistamine. If both are used, consider reducing the dose of zuranolone and advise against driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpheniramine
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Chlorpheniramine with Zuranolone?
MediHelp rates the interaction as moderate. Chlorpheniramine and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zuranolone causes somnolence and driving impairment, and sedating antihistamines add to these effects. The combination may increase CNS depression and psychomotor impairment.
How serious is the interaction between Chlorpheniramine and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-sedating antihistamine. If both are used, consider reducing the dose of zuranolone and advise against driving.
What other medicines interact with Chlorpheniramine?
MediHelp also lists interactions of Chlorpheniramine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Chlorpheniramine page.
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