Drug interactions
Chlorpropamide + Dapagliflozin-metformin
Severity: Moderate
Chlorpropamide and Dapagliflozin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding dapagliflozin-metformin to a sulfonylurea such as chlorpropamide increases the risk of hypoglycemia. Chlorpropamide is long-acting, so hypoglycemia can be prolonged.
What this interaction means in plain words
Chlorpropamide and Dapagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Dapagliflozin-metformin belongs to Endocrine.
Why it happens
Additive glucose-lowering through insulin secretion (sulfonylurea) combined with other antihyperglycemic mechanisms.
What to do
Consider reducing the sulfonylurea dose when starting dapagliflozin-metformin and counsel patients on hypoglycemia; monitor glucose closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Dapagliflozin-metformin?
MediHelp rates the interaction as moderate. Chlorpropamide and Dapagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding dapagliflozin-metformin to a sulfonylurea such as chlorpropamide increases the risk of hypoglycemia. Chlorpropamide is long-acting, so hypoglycemia can be prolonged.
How serious is the interaction between Chlorpropamide and Dapagliflozin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the sulfonylurea dose when starting dapagliflozin-metformin and counsel patients on hypoglycemia; monitor glucose closely.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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