Drug interactions
Chlorpropamide + Diflunisal
Severity: Moderate
Chlorpropamide and Diflunisal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates and some NSAIDs can enhance the glucose-lowering effect of sulfonylureas. Chlorpropamide has a long half-life, so hypoglycemia can be prolonged.
What this interaction means in plain words
Chlorpropamide and Diflunisal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Diflunisal belongs to Musculoskeletal.
Why it happens
Possible displacement of chlorpropamide from plasma proteins and reduced renal prostaglandin-mediated clearance, together with intrinsic salicylate glucose-lowering effects.
What to do
Monitor blood glucose more frequently when starting or stopping diflunisal, and reduce the chlorpropamide dose if hypoglycemia occurs. Counsel the patient on symptoms of hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Diflunisal?
MediHelp rates the interaction as moderate. Chlorpropamide and Diflunisal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salicylates and some NSAIDs can enhance the glucose-lowering effect of sulfonylureas. Chlorpropamide has a long half-life, so hypoglycemia can be prolonged.
How serious is the interaction between Chlorpropamide and Diflunisal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when starting or stopping diflunisal, and reduce the chlorpropamide dose if hypoglycemia occurs. Counsel the patient on symptoms of hypoglycemia.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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