Drug interactions
Chlorpropamide + Doxepin
Severity: Minor
Chlorpropamide and Doxepin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants have occasionally been associated with hypoglycemia or changes in glucose control in patients on antidiabetic drugs. The interaction is poorly documented, and may also mask hypoglycemia symptoms through anticholinergic effects.
What this interaction means in plain words
Chlorpropamide and Doxepin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorpropamide belongs to Endocrine; Doxepin belongs to Dermatology.
Why it happens
Possible additive hypoglycemic effect; mechanism not firmly established.
What to do
Monitor blood glucose when doxepin is started or stopped. Adjust the sulfonylurea dose if glucose changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlorpropamide
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Chlorpropamide with Doxepin?
MediHelp rates the interaction as minor. Chlorpropamide and Doxepin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants have occasionally been associated with hypoglycemia or changes in glucose control in patients on antidiabetic drugs. The interaction is poorly documented, and may also mask hypoglycemia symptoms through anticholinergic effects.
How serious is the interaction between Chlorpropamide and Doxepin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when doxepin is started or stopped. Adjust the sulfonylurea dose if glucose changes.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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