Drug interactions
Chlorpropamide + Enalapril-hydrochlorothiazide
Severity: Moderate
Chlorpropamide and Enalapril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and enhance the glucose lowering effect of sulfonylureas, raising the risk of hypoglycemia. Chlorpropamide has a long half-life, so hypoglycemia may be prolonged. Hydrochlorothiazide can in contrast worsen glycemic control and also raises the risk of hyponatremia with chlorpropamide.
What this interaction means in plain words
Chlorpropamide and Enalapril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Enalapril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
ACE inhibition enhances insulin sensitivity, adding to sulfonylurea hypoglycemic effect, while thiazides cause opposing hyperglycemia and additive hyponatremia.
What to do
Monitor blood glucose closely, especially after starting or changing the ACE inhibitor, and reduce the chlorpropamide dose if hypoglycemia occurs. Check serum sodium periodically.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chlorpropamide and Enalapril-hydrochlorothiazide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Enalapril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Chlorpropamide and Enalapril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can improve insulin sensitivity and enhance the glucose lowering effect of sulfonylureas, raising the risk of hypoglycemia. Chlorpropamide has a long half-life, so hypoglycemia may be prolonged. Hydrochlorothiazide can in contrast worsen glycemic control and also raises the risk of hyponatremia with chlorpropamide.
How serious is the interaction between Chlorpropamide and Enalapril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely, especially after starting or changing the ACE inhibitor, and reduce the chlorpropamide dose if hypoglycemia occurs. Check serum sodium periodically.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
