Drug interactions
Chlorpropamide + Etodolac
Severity: Moderate
Chlorpropamide and Etodolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may enhance the glucose-lowering effect of sulfonylureas such as chlorpropamide, increasing the risk of hypoglycemia. Chlorpropamide has a long half-life, so episodes may be prolonged.
What this interaction means in plain words
Chlorpropamide and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Etodolac belongs to Musculoskeletal.
Why it happens
Possible displacement of the sulfonylurea from plasma protein binding and reduced renal clearance; the mechanism is not fully established for etodolac.
What to do
Monitor blood glucose when etodolac is started or stopped and counsel the patient on hypoglycemia symptoms. Reduce the sulfonylurea dose if glucose falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Etodolac?
MediHelp rates the interaction as moderate. Chlorpropamide and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may enhance the glucose-lowering effect of sulfonylureas such as chlorpropamide, increasing the risk of hypoglycemia. Chlorpropamide has a long half-life, so episodes may be prolonged.
How serious is the interaction between Chlorpropamide and Etodolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when etodolac is started or stopped and counsel the patient on hypoglycemia symptoms. Reduce the sulfonylurea dose if glucose falls.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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