Drug interactions
Chlorpropamide + Fluoxetine
Severity: Moderate
Chlorpropamide and Fluoxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine can enhance glucose-lowering and cause hypoglycemia in patients on antidiabetic drugs. Fluoxetine also inhibits CYP2C9, which metabolizes sulfonylureas, so chlorpropamide exposure may increase. Hypoglycemia can be prolonged because chlorpropamide has a long half-life.
What this interaction means in plain words
Chlorpropamide and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Fluoxetine belongs to Central Nervous System.
Why it happens
Improved glycemic effects of SSRIs plus possible CYP2C9 inhibition reducing sulfonylurea clearance.
What to do
Monitor blood glucose closely when starting or stopping fluoxetine and lower the chlorpropamide dose if hypoglycemia occurs. Educate the patient on hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Fluoxetine?
MediHelp rates the interaction as moderate. Chlorpropamide and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoxetine can enhance glucose-lowering and cause hypoglycemia in patients on antidiabetic drugs. Fluoxetine also inhibits CYP2C9, which metabolizes sulfonylureas, so chlorpropamide exposure may increase. Hypoglycemia can be prolonged because chlorpropamide has a long half-life.
How serious is the interaction between Chlorpropamide and Fluoxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting or stopping fluoxetine and lower the chlorpropamide dose if hypoglycemia occurs. Educate the patient on hypoglycemia symptoms.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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