Drug interactions
Chlorpropamide + Indomethacin
Severity: Moderate
Chlorpropamide and Indomethacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indomethacin may enhance the glucose-lowering effect of chlorpropamide, raising hypoglycemia risk. Chlorpropamide has a long half-life so episodes can be prolonged.
What this interaction means in plain words
Chlorpropamide and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Indomethacin belongs to Musculoskeletal.
Why it happens
Possible protein-binding displacement and prostaglandin effects on insulin secretion; the mechanism is not firmly established.
What to do
Monitor blood glucose closely when indomethacin is started or stopped and reduce the chlorpropamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chlorpropamide and Indomethacin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Indomethacin?
MediHelp rates the interaction as moderate. Chlorpropamide and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indomethacin may enhance the glucose-lowering effect of chlorpropamide, raising hypoglycemia risk. Chlorpropamide has a long half-life so episodes can be prolonged.
How serious is the interaction between Chlorpropamide and Indomethacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when indomethacin is started or stopped and reduce the chlorpropamide dose if hypoglycemia occurs.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
