Drug interactions
Clozapine + Insulin degludec-insulin aspart
Severity: Major
Clozapine and Insulin degludec-insulin aspart: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine is strongly associated with hyperglycemia, new-onset diabetes and in some cases ketoacidosis. It can substantially reduce the effectiveness of insulin and raise insulin requirements.
What this interaction means in plain words
Clozapine and Insulin degludec-insulin aspart can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clozapine belongs to Central Nervous System; Insulin degludec-insulin aspart belongs to Endocrine.
Why it happens
Clozapine causes insulin resistance, weight gain and possibly impaired beta-cell function, antagonizing insulin's action.
What to do
Monitor blood glucose frequently, particularly at initiation and with dose changes, and titrate insulin upward as needed. Monitor for signs of ketoacidosis.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
- Insulin degludec-insulin aspart + Pramlintide Major
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Insulin degludec-insulin aspart?
MediHelp rates the interaction as major. Clozapine and Insulin degludec-insulin aspart can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clozapine is strongly associated with hyperglycemia, new-onset diabetes and in some cases ketoacidosis. It can substantially reduce the effectiveness of insulin and raise insulin requirements.
How serious is the interaction between Clozapine and Insulin degludec-insulin aspart?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently, particularly at initiation and with dose changes, and titrate insulin upward as needed. Monitor for signs of ketoacidosis.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Diazoxide, Ethanol. The full list is on the Insulin degludec-insulin aspart page.
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