Drug interactions
Chlorpropamide + Ketoprofen
Severity: Moderate
Chlorpropamide and Ketoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may enhance the glucose-lowering effect of sulfonylureas such as chlorpropamide, leading to hypoglycemia. Chlorpropamide has a long half-life, so hypoglycemia may be prolonged.
What this interaction means in plain words
Chlorpropamide and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Ketoprofen belongs to Musculoskeletal.
Why it happens
Possible displacement of the sulfonylurea from plasma protein binding and reduced renal clearance; prostaglandin effects on insulin secretion may contribute.
What to do
Monitor blood glucose when starting or stopping ketoprofen and counsel the patient on hypoglycemia symptoms. Reduce the chlorpropamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Ketoprofen?
MediHelp rates the interaction as moderate. Chlorpropamide and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may enhance the glucose-lowering effect of sulfonylureas such as chlorpropamide, leading to hypoglycemia. Chlorpropamide has a long half-life, so hypoglycemia may be prolonged.
How serious is the interaction between Chlorpropamide and Ketoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping ketoprofen and counsel the patient on hypoglycemia symptoms. Reduce the chlorpropamide dose if hypoglycemia occurs.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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