Drug interactions
Chlorpropamide + Maprotiline
Severity: Minor
Chlorpropamide and Maprotiline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antidepressants may alter glycemic control, and an enhanced hypoglycemic effect of sulfonylureas has been suggested. Clinically important hypoglycemia is uncommon, but chlorpropamide has a long half-life.
What this interaction means in plain words
Chlorpropamide and Maprotiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorpropamide belongs to Endocrine; Maprotiline belongs to Central Nervous System.
Why it happens
Possible additive pharmacodynamic effect on glucose regulation; not well established.
What to do
Monitor blood glucose when maprotiline is started or stopped and adjust the chlorpropamide dose if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Maprotiline?
MediHelp rates the interaction as minor. Chlorpropamide and Maprotiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antidepressants may alter glycemic control, and an enhanced hypoglycemic effect of sulfonylureas has been suggested. Clinically important hypoglycemia is uncommon, but chlorpropamide has a long half-life.
How serious is the interaction between Chlorpropamide and Maprotiline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when maprotiline is started or stopped and adjust the chlorpropamide dose if control changes.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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