Drug interactions
Chlorpropamide + Oxaprozin
Severity: Moderate
Chlorpropamide and Oxaprozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may enhance the glucose-lowering effect of sulfonylureas, raising the risk of hypoglycemia. Chlorpropamide has a long half-life, so hypoglycemia may be prolonged.
What this interaction means in plain words
Chlorpropamide and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Oxaprozin belongs to Musculoskeletal.
Why it happens
Oxaprozin is highly protein bound and may displace sulfonylurea from albumin and possibly reduce its clearance, increasing free drug.
What to do
Monitor blood glucose when oxaprozin is started or stopped and teach patients to recognize hypoglycemia. Reduce the sulfonylurea dose if glucose falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Oxaprozin?
MediHelp rates the interaction as moderate. Chlorpropamide and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may enhance the glucose-lowering effect of sulfonylureas, raising the risk of hypoglycemia. Chlorpropamide has a long half-life, so hypoglycemia may be prolonged.
How serious is the interaction between Chlorpropamide and Oxaprozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when oxaprozin is started or stopped and teach patients to recognize hypoglycemia. Reduce the sulfonylurea dose if glucose falls.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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