Drug interactions
Chlorpropamide + Pivmecillinam
Severity: Minor
Chlorpropamide and Pivmecillinam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are acidic compounds eliminated partly through renal tubular secretion, so competition is possible. Clinically significant changes are not well documented.
What this interaction means in plain words
Chlorpropamide and Pivmecillinam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorpropamide belongs to Endocrine; Pivmecillinam belongs to Anti Bacterial.
Why it happens
Theoretical competition for renal tubular secretion of organic anions.
What to do
No dose change is generally needed. Be alert to changes in glucose control during the antibiotic course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlorpropamide
Other interactions of Pivmecillinam
- Doxycycline + Pivmecillinam Moderate
- Minocycline + Pivmecillinam Moderate
- Pivmecillinam + Probenecid Moderate
- Pivmecillinam + Tetracycline Moderate
- Acetylsalicylic acid + Pivmecillinam Minor
- Acyclovir + Pivmecillinam Minor
Frequently asked questions
Can I take Chlorpropamide with Pivmecillinam?
MediHelp rates the interaction as minor. Chlorpropamide and Pivmecillinam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both agents are acidic compounds eliminated partly through renal tubular secretion, so competition is possible. Clinically significant changes are not well documented.
How serious is the interaction between Chlorpropamide and Pivmecillinam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed. Be alert to changes in glucose control during the antibiotic course.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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