Drug interactions
Chlorpropamide + Prednisone
Severity: Moderate
Chlorpropamide and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prednisone raises blood glucose and can reduce the effectiveness of chlorpropamide. Patients may need higher antidiabetic doses during steroid treatment.
What this interaction means in plain words
Chlorpropamide and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Prednisone belongs to Endocrine.
Why it happens
Glucocorticoid-induced insulin resistance and increased hepatic glucose production oppose sulfonylurea action.
What to do
Monitor blood glucose more frequently and adjust the antidiabetic regimen. Lower the dose again after the steroid is tapered to avoid hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Prednisone?
MediHelp rates the interaction as moderate. Chlorpropamide and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prednisone raises blood glucose and can reduce the effectiveness of chlorpropamide. Patients may need higher antidiabetic doses during steroid treatment.
How serious is the interaction between Chlorpropamide and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently and adjust the antidiabetic regimen. Lower the dose again after the steroid is tapered to avoid hypoglycemia.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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