Drug interactions
Chlorpropamide + Probenecid
Severity: Moderate
Chlorpropamide and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid can reduce the renal excretion of chlorpropamide and its active metabolites, prolonging its glucose-lowering effect. Chlorpropamide has a long half-life, so hypoglycemia may be prolonged and more severe.
What this interaction means in plain words
Chlorpropamide and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Probenecid belongs to Genitourinary.
Why it happens
Probenecid inhibits renal tubular secretion of chlorpropamide, increasing its exposure.
What to do
Monitor blood glucose closely when starting or stopping probenecid. Reduce the chlorpropamide dose if hypoglycemia occurs, or choose a shorter-acting agent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Probenecid?
MediHelp rates the interaction as moderate. Chlorpropamide and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid can reduce the renal excretion of chlorpropamide and its active metabolites, prolonging its glucose-lowering effect. Chlorpropamide has a long half-life, so hypoglycemia may be prolonged and more severe.
How serious is the interaction between Chlorpropamide and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting or stopping probenecid. Reduce the chlorpropamide dose if hypoglycemia occurs, or choose a shorter-acting agent.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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