Drug interactions
Chlorpropamide + Rifapentine
Severity: Moderate
Chlorpropamide and Rifapentine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine is an enzyme inducer that may lower sulfonylurea concentrations and weaken glucose control. The induction is somewhat less than with rifampin but is still relevant.
What this interaction means in plain words
Chlorpropamide and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Rifapentine belongs to Anti Bacterial.
Why it happens
Rifapentine induces CYP2C9 and related enzymes, increasing chlorpropamide metabolism.
What to do
Monitor blood glucose during and after rifapentine therapy. Increase the chlorpropamide dose if control worsens, and reduce it after rifapentine is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpropamide
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Chlorpropamide with Rifapentine?
MediHelp rates the interaction as moderate. Chlorpropamide and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifapentine is an enzyme inducer that may lower sulfonylurea concentrations and weaken glucose control. The induction is somewhat less than with rifampin but is still relevant.
How serious is the interaction between Chlorpropamide and Rifapentine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during and after rifapentine therapy. Increase the chlorpropamide dose if control worsens, and reduce it after rifapentine is discontinued.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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