Drug interactions
Chlorpropamide + Ritonavir
Severity: Moderate
Chlorpropamide and Ritonavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir has mixed effects on drug-metabolizing enzymes and can alter sulfonylurea exposure unpredictably. Protease inhibitors also cause insulin resistance and hyperglycemia, which can reduce chlorpropamide effectiveness.
What this interaction means in plain words
Chlorpropamide and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Ritonavir belongs to Anti Virals.
Why it happens
Variable enzyme inhibition and induction by ritonavir, together with protease inhibitor-related insulin resistance.
What to do
Monitor blood glucose frequently when ritonavir is started or stopped. Titrate the chlorpropamide dose to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpropamide
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Chlorpropamide with Ritonavir?
MediHelp rates the interaction as moderate. Chlorpropamide and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir has mixed effects on drug-metabolizing enzymes and can alter sulfonylurea exposure unpredictably. Protease inhibitors also cause insulin resistance and hyperglycemia, which can reduce chlorpropamide effectiveness.
How serious is the interaction between Chlorpropamide and Ritonavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently when ritonavir is started or stopped. Titrate the chlorpropamide dose to response.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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